Fecal Microbiota Transplantation Slows the Progression of HBV-Related Liver Diseases and Induces Virologic Response in Patients with HBV Infection

Aims: Healthy gut microbiome plays a crucial role in the treatment of Hepatitis B Virus (HBV) infection and chronic liver disease. Based on existing studies, we aimed to explore difference efficacy Fecal Microbiota Transplantation (FMT) patients with different stages HBV-related Methods: In this study, 10 HBV HBeAg-negative infection, 8 Chronic (CHB) hepatitis cirrhosis Child-Pugh score A, 9 B/C were treated FMT. Results: Our results demonstrated that continuous FMT improved function, controlled replication HBV-DNA, enhanced intestinal mucosal barrier relieve degree fibrosis postponed progression The result 16S ribosomal RNA (rRNA) sequencing indicated individual genus composition bacteria feces gradually approached structure seen case healthy donors; number specific Operational Taxonomic Units (OTUs) stool samples decreased. Conclusion: study further confirmed could be novel effective strategy for infection.